Micafungin activity against Candida albicans with diverse azole resistance phenotypes
نویسندگان
چکیده
منابع مشابه
Micafungin activity against Candida albicans with diverse azole resistance phenotypes.
OBJECTIVES The purpose of this study was to investigate whether mechanisms of azole resistance in Candida albicans contribute to reduced micafungin activity in vitro. METHODS MICs were determined for a collection of strains with well-characterized mechanisms of azole resistance obtained from systemic, oral and vaginal infections. This collection of strains includes those with resistance-assoc...
متن کاملMicafungin at physiological serum concentrations shows antifungal activity against Candida albicans and Candida parapsilosis biofilms.
We assessed the in vitro activity of micafungin against preformed Candida biofilms by measuring the concentration of drug causing the most fungal damage and inhibition of regrowth. We studied 37 biofilm-producing Candida spp. strains from blood cultures. We showed that micafungin was active against planktonic and sessile forms of Candida albicans strains and moderately active against Candida pa...
متن کاملAzole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species
Within the limited antifungal armamentarium, the azole antifungals are the most frequent class used to treat Candida infections. Azole antifungals such as fluconazole are often preferred treatment for many Candida infections as they are inexpensive, exhibit limited toxicity, and are available for oral administration. There is, however, extensive documentation of intrinsic and developed resistan...
متن کاملProteomic analysis of azole resistance in Candida albicans clinical isolates.
Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthes...
متن کاملIn vitro activity of micafungin against planktonic and sessile Candida albicans isolates.
Planktonic and sessile susceptibilities to micafungin were determined for 30 clinical isolates of Candida albicans obtained from blood or other sterile sites. Planktonic and sessile MIC(90)s for micafungin were 0.125 and 1.0 microg/ml, respectively.
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2008
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkn156